The Rea1 Tadpole Loses Its Tail
نویسندگان
چکیده
More than 170 assembly factors aid the construction and maturation of yeast ribosomes. After these factors' functions are completed, they must be released from preribosomes. In this issue, Ulbrich et al. (2009) describe a mechanochemical process through which the AAA ATPase Rea1 induces release of an assembly protein complex from preribosomes.
منابع مشابه
Mechanochemical Removal of Ribosome Biogenesis Factors from Nascent 60S Ribosomal Subunits
The dynein-related AAA ATPase Rea1 is a preribosomal factor that triggers an unknown maturation step in 60S subunit biogenesis. Using electron microscopy, we show that Rea1's motor domain is docked to the pre-60S particle and its tail-like structure, harboring a metal ion-dependent adhesion site (MIDAS), protrudes from the preribosome. Typically, integrins utilize a MIDAS to bind extracellular ...
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ورودعنوان ژورنال:
- Cell
دوره 138 شماره
صفحات -
تاریخ انتشار 2009